Scientists at The University of Manchester have made an important new discovery about the brain's immune system that could lead to potential new treatments for stroke.
The study involved analyzing the role that inflammasomes (large protein complexes essential for the production of the anti-inflammatory protein interleukin-1) take in strokes.
Scientists have believed that Interleukin-1 contributes to cell death in the brain following a stroke.
The latest findings indicate that the inflammasome NLRP3, which was previously believed to be involved in inflammation and damage in the brain caused by stroke, is actually not involved. In fact it is the inflammasomes NLRC4 and AIM2 that contribute to brain injury.
The results were especially surprising because the researchers had long held that NLRC4 fought infections.
By better understanding how inflammation is regulated in the brain by inflammasomes, researchers can better develop drugs to limit the damage caused by inflammation.
In addition, the new discovery will also help researchers discover more about how inflammation is involved in brain injury and develop new drugs for the treatment of stroke. The findings may also be helpful with further research on Alzheimer's disease and depression, which may also be driven by inflammation of the brain. For more information, please visit the Medical News Today website.Resources